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《医学前沿(英文)》 2022年 第16卷 第6期 页码 969-974 doi: 10.1007/s11684-021-0912-z
关键词: severe malaria nigeria malaria mortality PfPR2-10 intermediate malaria transmission
Preface of special issue of the 10 th International Conference on CO 2 Utilization
Changjun LIU,
《化学科学与工程前沿(英文)》 2010年 第4卷 第2期 页码 109-109 doi: 10.1007/s11705-009-0258-6
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 410-422 doi: 10.1007/s11684-017-0527-6
Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusion protein causes lethal hyperfibrinolysis in acute promyelocytic leukemia (APL), but the mechanism is unclear. To facilitate the investigation of regulatory association between ANXA2 and promyelocytic leukemia/retinoic acid receptor a (PML/RARα) fusion protein, this work was performed to determine the transcription start site of ANXA2 promoter with rapid amplification of 5′-cDNA ends analysis. Zinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2 transcripts and translational expressions of both ANXA2 and S100A10, while S100A10 transcripts remained constitutive. The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higher than that by control pSG5 vector or wild-type RARα. The overexpression of ANXA2 in U937 transfected with full-length ANXA2 cDNA was associated with increased S100A10 subunit, although S100A10 transcripts remained constitutive. The tPA-dependent initial rate of plasmin generation (IRPG) in zinc-treated U937/PR9 increased by 2.13-fold, and cell invasiveness increased by 27.6%. Antibodies against ANXA2, S100A10, or combination of both all remarkably inhibited the IRPG and invasiveness in U937/PR9 and NB4. Treatment of zinc-induced U937/PR9 or circulating APL blasts with all-trans retinoic acid (ATRA) significantly reduced cell surface ANXA2 and S100A10 and associated reductions in IRPG and invasiveness. Thus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate S100A10. Increased AIIt promoted IRPG and invasiveness, both of which were partly abolished by antibodies against ANXA2 and S100A10 or by ATRA.
关键词: annexin A2-S100A10 heterotetramer PML/RARα fusion protein plasmin cell invasion acute promyelocytic leukemia
NO hydrogenation to NH over FeCu/TiO catalyst with improved activity
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1973-1985 doi: 10.1007/s11705-023-2364-2
关键词: NO hydrogenation synthetic ammonia 10Fe-xCu/TiO2 high selectivity
PM10 emissions from industrial coal-fired chain-grate boilers
Xinghua Li, Junzan Han, Lei Duan
《环境科学与工程前沿(英文)》 2017年 第11卷 第6期 doi: 10.1007/s11783-017-0966-y
关键词: coal-fired chain-grate boiler PM10 size distribution particulate emission control devices size-dependent collection efficiency
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
《医学前沿(英文)》 页码 957-971 doi: 10.1007/s11684-023-0988-8
关键词: DNAH10 mice motile cilia mutation primary ciliary dyskinesia
《医学前沿(英文)》 2022年 第16卷 第4期 页码 596-609 doi: 10.1007/s11684-021-0868-z
关键词: innate immune checkpoint Siglec10 kidney renal clear cell carcinoma
The most influential “Top 10 Events” in carbon neutrality and climate change in 2022
《能源前沿(英文)》 2023年 第17卷 第1期 页码 1-4 doi: 10.1007/s11708-023-0869-5
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
《医学前沿(英文)》 2008年 第2卷 第3期 页码 298-302 doi: 10.1007/s11684-008-0057-3
关键词: inflammatory presence interleukin-10 dose-dependent ox-LDL
《农业科学与工程前沿(英文)》 2022年 第9卷 第2期 页码 309-311 doi: 10.15302/J-FASE-2022440
以上海10 km2 的近零能耗区项目为例浅谈作为城市基础设施的人力- 能源-水资源联动系统的地理设计方案 Article
Perry Pei-Ju Yang, Cheryl Shu-Fang Chi, Yihan Wu, Steven Jige Quan
《工程(英文)》 2018年 第4卷 第2期 页码 182-189 doi: 10.1016/j.eng.2018.03.014
日益显著的气候变化对新的城市设计模式提出了巨大的挑战,我们需将如能源、水资源的使用效率等城市系统的性能元素纳入考虑范围。传统的城市设计模式注重形式的设计过程,却缺乏性能维度的考量。地理设计是一种新兴的方法,该方法更加强调系统性思维、数字技术与地理环境之间的联系。本文介绍了该领域大规模合作研究第一阶段的研究成果,并进一步提出了一种用于区域规模城市设计的地理设计方案,以整合可再生能源生产系统、能源消耗系统及雨水管理系统等,并兼顾了人类的城市生活体验。该方案结合了地理信息系统(GIS)、参数化建模技术和多学科设计优化(MDO)工具,可实现协同设计决策。为了实现近零能耗城市实验区的设计,该方案通过了测试案例的反复推演与调整。我们最终的方案有如下3 个特点:①集成的地理设计和参数化设计:方案采用参数化设计方法,通过自定义程序算法生成焦点尺度的原型,并应用地理设计来评估设计方案的性能;②关注设计流程:方案阐述了设计过程中的问题定义标准、信息的选择标准以及设计决策的制定标准;③多目标优化:测试案例通过性能建模生成指标,并通过多目标计算实验得出原理,从中我们可以得知如何改进该设计。本文总结了基于多学科设计优化(MDO)工具的城市设计方案和基础设施系统建模方案,并描述了随后的实施步骤。
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 24-32 doi: 10.1007/s11684-014-0312-8
In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.
关键词: osteopontin (OPN) hepatocellular carcinoma metastasis prognosis therapeutic target biomarker genetic polymorphism
NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation
Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li
《医学前沿(英文)》 2019年 第13卷 第6期 页码 646-657 doi: 10.1007/s11684-018-0643-y
关键词: androgen-independent prostate cancer normal epithelial cell-specific 1/kallikrein 10 sodium/iodide symporter radiation therapy proliferation
山奈酚作为新型ADAM10抑制剂治疗金黄色葡萄球菌感染 Article
王婷婷, 王建锋, 许湘竹, 蒋帆, 吕红发, 齐清辉, 张灿, 吕强华, 邓旭明
《工程(英文)》 2023年 第28卷 第9期 页码 206-221 doi: 10.1016/j.eng.2023.03.006
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《医学前沿(英文)》 2012年 第6卷 第1期 页码 94-99 doi: 10.1007/s11684-012-0181-y
Systematic reviews and meta-analyses are playing an increasingly important role in clinical research and practice. This study aimed to measure the scientific production of systematic review and meta-analysis from the three major regions of China: the Mainland (ML), Hong Kong (HK), and Taiwan (TW). English articles on systematic review and meta-analysis from ML, HK, and TW from 2001 to 2010 were retrieved from the PubMed database. The total number of articles, impact factors (IF), and articles published in high-impact journals were conducted for quantity and quality comparisons among the three regions. There were 1 587 published articles from ML (1 292), HK (203), and TW (92) during the past ten years. The annual total numbers of articles in the three regions increased significantly from 2001 to 2010 (from 13 to 677). The number of articles from ML has exceeded that from TW since 2001, and surpassed that from HK in 2003. The accumulated IF of articles from ML (3 488.24) was higher than those from HK (493.16) and TW (216.39). HK had the highest average IF of 3.31, followed by ML of 2.90 and TW of 2.85. Researchers from HK published a larger proportion of papers in high-impact journals than those from ML and TW. The Cochrane Database of Systematic Reviews was the most popular journal in China. Chinese authors have been very active to enhance the systematic review and meta-analysis research over the past ten years, especially in ML. The gap between ML and the other two regions has been narrowed. But there is still considerable room for Chinese authors to improve their studies on systematic review and meta-analysis.
关键词: systematic review meta-analysis China Chinese impact factor
标题 作者 时间 类型 操作
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in
期刊论文
Preface of special issue of the 10 th International Conference on CO 2 Utilization
Changjun LIU,
期刊论文
Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent
null
期刊论文
Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient
期刊论文
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
期刊论文
GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021
期刊论文
以上海10 km2 的近零能耗区项目为例浅谈作为城市基础设施的人力- 能源-水资源联动系统的地理设计方案
Perry Pei-Ju Yang, Cheryl Shu-Fang Chi, Yihan Wu, Steven Jige Quan
期刊论文
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
null
期刊论文
NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation
Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li
期刊论文